Thiamin diphosphate in biological chemistry: applications in biocatalysis, coenzyme analogues as mechanistic probes and natural derivatives of thiamin.
نویسنده
چکیده
ed and indexed by Biological & Agricultural Index, Biosis, CAS, ISI (Current
منابع مشابه
Benefits of Thiamin (Vitamin B1) Administration in Neurodegenerative Diseases May Be Due to Both the Coenzyme and Non-coenzyme Roles of Thiamin
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Thiamin (vitamin B1) is a pharmacological agent boosting central metabolism through the action of the coenzyme thiamin diphosphate (ThDP). However, positive effects, including improved cognition, of high thiamin doses in neurodegeneration may be observed without increased ThDP or ThDP-dependent enzymes in brain. Here, we determine protein partners and metabolic pathways where thiamin acts beyon...
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Single crystals of the thiamin diphosphate (the vitamin B1 coenzyme)-dependent enzyme pyruvate decarboxylase (EC 4.1.1.1) from brewers' yeast have been grown using polyethylene glycol as a precipitating agent. Crystals of the homotetrameric version alpha 4 of the holoenzyme are triclinic, space group P1, with cell constants a = 81.0, b = 82.4, c = 116.6 A, alpha = 69.5 beta = 72.6, gamma = 62.4...
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ورودعنوان ژورنال:
- The FEBS journal
دوره 276 11 شماره
صفحات -
تاریخ انتشار 2009